New adipogenic cocktail that produces functional adipocytes from mesechymal stromal cells

Multipotent mesechymal stromal cells (MSCs) have been recognized as a source of adipocytes both in vivo and in vitro. It is reported that, simultaneous activation of canonical signaling pathways by dexamethasone through the glucocorticoid receptor and CCAAT-enchancer-binding proteins (C/EBPs) and rosiglitazone through peroxisome proliferator-activated receptor gamma (PPAR-gamma), is sufficient for inducing adipogenic differentiation from MSCs, producing functional adipocytes.